{
  "_id": "6a1f1837b401979e7341eca6",
  "Package": "hesim",
  "Type": "Package",
  "Title": "Health Economic Simulation Modeling and Decision Analysis",
  "Version": "0.5.8",
  "Authors@R": "c(\nperson(\"Devin\", \"Incerti\", , \"devin.incerti@gmail.com\", role = c(\"aut\", \"cre\")),\nperson(\"Jeroen P.\", \"Jansen\", role = \"aut\"),\nperson(\"Mark\", \"Clements\", role = \"aut\"),\nperson(given = \"R Core Team\", role = \"ctb\",\ncomment=\"hesim uses some slightly modified C functions from base R\")\n)",
  "Description": "A modular and computationally efficient R package for\nparameterizing, simulating, and analyzing health economic\nsimulation models. The package supports cohort discrete time\nstate transition models (Briggs et al. 1998)\n<doi:10.2165/00019053-199813040-00003>, N-state partitioned\nsurvival models (Glasziou et al. 1990)\n<doi:10.1002/sim.4780091106>, and individual-level continuous\ntime state transition models (Siebert et al. 2012)\n<doi:10.1016/j.jval.2012.06.014>, encompassing both Markov\n(time-homogeneous and time-inhomogeneous) and semi-Markov\nprocesses. Decision uncertainty from a cost-effectiveness\nanalysis is quantified with standard graphical and tabular\nsummaries of a probabilistic sensitivity analysis (Claxton et\nal. 2005, Barton et al. 2008) <doi:10.1002/hec.985>,\n<doi:10.1111/j.1524-4733.2008.00358.x>. Use of C++ and\ndata.table make individual-patient simulation, probabilistic\nsensitivity analysis, and incorporation of patient\nheterogeneity fast.",
  "URL": "https://hesim-dev.github.io/hesim/,\nhttps://github.com/hesim-dev/hesim",
  "BugReports": "https://github.com/hesim-dev/hesim/issues",
  "License": "GPL-3",
  "LazyData": "true",
  "VignetteBuilder": "knitr",
  "Roxygen": "list(markdown = TRUE)",
  "RoxygenNote": "7.3.3",
  "Config/pak/sysreqs": "libicu-dev",
  "Repository": "https://hesim-dev.r-universe.dev",
  "Date/Publication": "2026-01-16 23:41:05 UTC",
  "RemoteUrl": "https://github.com/hesim-dev/hesim",
  "RemoteRef": "HEAD",
  "RemoteSha": "676630b6247c8fedec5deed8f23a157e722b392c",
  "NeedsCompilation": "yes",
  "Packaged": {
    "Date": "2026-05-17 05:47:14 UTC",
    "User": "root"
  },
  "Author": "Devin Incerti [aut, cre],\nJeroen P. Jansen [aut],\nMark Clements [aut],\nR Core Team [ctb] (hesim uses some slightly modified C functions from\nbase R)",
  "Maintainer": "Devin Incerti <devin.incerti@gmail.com>",
  "MD5sum": "7800482a1bd5c3ca3ab8ace401e4f422",
  "_user": "hesim-dev",
  "_type": "src",
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  "_created": "2026-05-17T05:47:14.000Z",
  "_published": "2026-06-02T17:51:51.693Z",
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  "_status": "success",
  "_host": "GitHub-Actions",
  "_upstream": "https://github.com/hesim-dev/hesim",
  "_commit": {
    "id": "676630b6247c8fedec5deed8f23a157e722b392c",
    "author": "Devin Incerti <devin.incerti@gmail.com>",
    "committer": "GitHub <noreply@github.com>",
    "message": "Merge pull request #147 from hesim-dev/v0.5.8\n\nchore: release V0.5.8",
    "time": 1768606865
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      "package": "data.table",
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  "_selfowned": true,
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  "_topics": [
    "health-economic-evaluation",
    "microsimulation",
    "simulation-modeling",
    "cpp"
  ],
  "_stars": 76,
  "_contributors": [
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    "type": "organization",
    "name": "hesim-dev",
    "description": "Simulation software for epidemiology and health economics"
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    "source": "https://cranlogs.r-pkg.org/downloads/total/last-month/hesim"
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  "_devurl": "https://github.com/hesim-dev/hesim",
  "_pkgdown": "https://hesim-dev.github.io/hesim/",
  "_searchresults": 50,
  "_rbuild": "4.6.0",
  "_assets": [
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    "extra/citation.html",
    "extra/citation.json",
    "extra/citation.txt",
    "extra/contents.json",
    "extra/hesim.html",
    "extra/readme.html",
    "extra/readme.md",
    "manual.pdf"
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  "_homeurl": "https://github.com/hesim-dev/hesim",
  "_realowner": "hesim-dev",
  "_cranurl": true,
  "_releases": [
    {
      "version": "0.1.0",
      "date": "2017-12-03"
    },
    {
      "version": "0.2.0",
      "date": "2019-03-29"
    },
    {
      "version": "0.2.1",
      "date": "2019-07-03"
    },
    {
      "version": "0.2.2",
      "date": "2019-11-26"
    },
    {
      "version": "0.2.3",
      "date": "2020-03-17"
    },
    {
      "version": "0.3.0",
      "date": "2020-05-25"
    },
    {
      "version": "0.3.1",
      "date": "2020-06-03"
    },
    {
      "version": "0.4.0",
      "date": "2020-09-29"
    },
    {
      "version": "0.4.1",
      "date": "2020-10-05"
    },
    {
      "version": "0.4.2",
      "date": "2020-12-07"
    },
    {
      "version": "0.5.0",
      "date": "2021-02-17"
    },
    {
      "version": "0.5.1",
      "date": "2021-07-26"
    },
    {
      "version": "0.5.2",
      "date": "2022-03-31"
    },
    {
      "version": "0.5.3",
      "date": "2022-09-03"
    },
    {
      "version": "0.5.4",
      "date": "2024-02-12"
    },
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      "version": "0.5.5",
      "date": "2024-09-18"
    },
    {
      "version": "0.5.6",
      "date": "2025-09-28"
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    {
      "version": "0.5.7",
      "date": "2025-10-11"
    },
    {
      "version": "0.5.8",
      "date": "2026-01-13"
    }
  ],
  "_exports": [
    "apply_rr",
    "as_array3",
    "as_pfs_os",
    "as_tbl2",
    "as.data.table",
    "autoplot",
    "cea",
    "cea_pw",
    "CohortDtstm",
    "CohortDtstmTrans",
    "create_CohortDtstm",
    "create_CohortDtstmTrans",
    "create_IndivCtstmTrans",
    "create_input_mats",
    "create_lines_dt",
    "create_params",
    "create_PsmCurves",
    "create_StateVals",
    "create_trans_dt",
    "CtstmTrans",
    "define_model",
    "define_rng",
    "define_tparams",
    "dweibullNMA",
    "eval_model",
    "eval_rng",
    "expand",
    "expmat",
    "fast_rgengamma",
    "flexsurvreg_list",
    "formula_list",
    "get_labels",
    "hesim_data",
    "hesim_survdists",
    "hweibullNMA",
    "HweibullNMA",
    "icea",
    "icea_pw",
    "icer",
    "icer_tbl",
    "id_attributes",
    "incr_effect",
    "IndivCtstm",
    "IndivCtstmTrans",
    "input_mats",
    "lm_list",
    "mean_weibullNMA",
    "mom_beta",
    "mom_gamma",
    "multinom_list",
    "params_lm",
    "params_mlogit",
    "params_mlogit_list",
    "params_surv",
    "params_surv_list",
    "partsurvfit",
    "plot_ceac",
    "plot_ceaf",
    "plot_ceplane",
    "plot_evpi",
    "Psm",
    "PsmCurves",
    "pweibullNMA",
    "qmatrix",
    "qweibullNMA",
    "rcat",
    "rdirichlet_mat",
    "rmst_weibullNMA",
    "rpwexp",
    "rweibullNMA",
    "set_labels",
    "sim_costs",
    "sim_ev",
    "sim_qalys",
    "sim_stateprobs",
    "stateval_tbl",
    "StateVals",
    "surv_quantile",
    "survival",
    "time_intervals",
    "tparams_mean",
    "tparams_transprobs",
    "tpmatrix",
    "tpmatrix_id",
    "tpmatrix_names"
  ],
  "_datasets": [
    {
      "name": "mstate3_exdata",
      "title": "Example data for a reversible 3-state multi-state model",
      "object": "mstate3_exdata",
      "class": [
        "list"
      ],
      "fields": [],
      "table": false,
      "tojson": true
    },
    {
      "name": "multinom3_exdata",
      "title": "Example data for a 3-state multinomial model",
      "object": "multinom3_exdata",
      "class": [
        "list"
      ],
      "fields": [],
      "table": false,
      "tojson": true
    },
    {
      "name": "onc3",
      "title": "Multi-state oncology data for 3-state model",
      "object": "onc3",
      "class": [
        "data.table",
        "data.frame"
      ],
      "fields": [
        "from",
        "to",
        "strategy_name",
        "female",
        "age",
        "patient_id",
        "time_start",
        "time_stop",
        "status",
        "transition_id",
        "strategy_id",
        "time"
      ],
      "rows": 7510,
      "table": true,
      "tojson": true
    },
    {
      "name": "onc3p",
      "title": "Multi-state panel oncology data for 3-state model",
      "object": "onc3p",
      "class": [
        "data.table",
        "data.frame"
      ],
      "fields": [
        "state",
        "strategy_name",
        "female",
        "age",
        "patient_id",
        "time",
        "strategy_id",
        "state_id"
      ],
      "rows": 7510,
      "table": true,
      "tojson": true
    },
    {
      "name": "psm4_exdata",
      "title": "Example data for a 4-state partitioned survival model",
      "object": "psm4_exdata",
      "class": [
        "list"
      ],
      "fields": [],
      "table": false,
      "tojson": true
    }
  ],
  "_help": [
    {
      "page": "apply_rr",
      "title": "Apply relative risks to transition probability matrices",
      "topics": [
        "apply_rr"
      ]
    },
    {
      "page": "as_array3",
      "title": "Convert between 2D tabular objects and 3D arrays",
      "topics": [
        "as_array3",
        "as_tbl2"
      ]
    },
    {
      "page": "as_pfs_os",
      "title": "Convert multi-state data to PFS and OS data",
      "topics": [
        "as_pfs_os"
      ]
    },
    {
      "page": "as.data.table.tparams_transprobs",
      "title": "Coerce to 'data.table'",
      "topics": [
        "as.data.table.tparams_transprobs"
      ]
    },
    {
      "page": "autoplot.stateprobs",
      "title": "Plot state probabilities",
      "topics": [
        "autoplot.stateprobs"
      ]
    },
    {
      "page": "autoplot.survival",
      "title": "Plot survival curves",
      "topics": [
        "autoplot.survival"
      ]
    },
    {
      "page": "ce",
      "title": "A cost-effectiveness object",
      "topics": [
        "ce"
      ]
    },
    {
      "page": "cea",
      "title": "Cost-effectiveness analysis",
      "topics": [
        "cea",
        "cea.ce",
        "cea.default",
        "cea_pw",
        "cea_pw.ce",
        "cea_pw.default"
      ]
    },
    {
      "page": "CohortDtstm",
      "title": "Cohort discrete time state transition model",
      "topics": [
        "CohortDtstm"
      ]
    },
    {
      "page": "CohortDtstmTrans",
      "title": "Transitions for a cohort discrete time state transition model",
      "topics": [
        "CohortDtstmTrans"
      ]
    },
    {
      "page": "costs",
      "title": "Costs object",
      "topics": [
        "costs"
      ]
    },
    {
      "page": "create_CohortDtstm",
      "title": "Create 'CohortDtstm' object",
      "topics": [
        "create_CohortDtstm",
        "create_CohortDtstm.model_def"
      ]
    },
    {
      "page": "create_CohortDtstmTrans",
      "title": "Create 'CohortDtstmTrans' object",
      "topics": [
        "create_CohortDtstmTrans",
        "create_CohortDtstmTrans.msm",
        "create_CohortDtstmTrans.multinom_list",
        "create_CohortDtstmTrans.params_mlogit_list"
      ]
    },
    {
      "page": "create_IndivCtstmTrans",
      "title": "Create 'IndivCtstmTrans' object",
      "topics": [
        "create_IndivCtstmTrans",
        "create_IndivCtstmTrans.flexsurvreg",
        "create_IndivCtstmTrans.flexsurvreg_list",
        "create_IndivCtstmTrans.params_surv",
        "create_IndivCtstmTrans.params_surv_list"
      ]
    },
    {
      "page": "create_params",
      "title": "Create a parameter object from a fitted model",
      "topics": [
        "create_params",
        "create_params.flexsurvreg",
        "create_params.flexsurvreg_list",
        "create_params.lm",
        "create_params.multinom",
        "create_params.multinom_list",
        "create_params.partsurvfit"
      ]
    },
    {
      "page": "create_PsmCurves",
      "title": "Create 'PsmCurves' object",
      "topics": [
        "create_PsmCurves",
        "create_PsmCurves.flexsurvreg_list",
        "create_PsmCurves.params_surv_list"
      ]
    },
    {
      "page": "create_StateVals",
      "title": "Create a 'StateVals' object",
      "topics": [
        "create_StateVals",
        "create_StateVals.lm",
        "create_StateVals.stateval_tbl"
      ]
    },
    {
      "page": "create_trans_dt",
      "title": "Create a data table of health state transitions",
      "topics": [
        "create_trans_dt"
      ]
    },
    {
      "page": "define_model",
      "title": "Define and evaluate model expression",
      "topics": [
        "define_model",
        "eval_model"
      ]
    },
    {
      "page": "define_rng",
      "title": "Define and evaluate random number generation expressions",
      "topics": [
        "define_rng",
        "eval_rng"
      ]
    },
    {
      "page": "define_tparams",
      "title": "Define and evaluate transformed parameter expressions",
      "topics": [
        "define_tparams",
        "eval_tparams"
      ]
    },
    {
      "page": "disprog",
      "title": "Disease progression object",
      "topics": [
        "disprog"
      ]
    },
    {
      "page": "expand.hesim_data",
      "title": "Expand hesim_data",
      "topics": [
        "expand.hesim_data"
      ]
    },
    {
      "page": "expmat",
      "title": "Matrix exponential",
      "topics": [
        "expmat"
      ]
    },
    {
      "page": "fast_rgengamma",
      "title": "Random generation for generalized gamma distribution",
      "topics": [
        "fast_rgengamma"
      ]
    },
    {
      "page": "flexsurvreg_list",
      "title": "List of 'flexsurvreg' objects",
      "topics": [
        "flexsurvreg_list"
      ]
    },
    {
      "page": "get_labels",
      "title": "Get value labels",
      "topics": [
        "get_labels"
      ]
    },
    {
      "page": "hesim_data",
      "title": "Data for health economic simulation modeling",
      "topics": [
        "hesim_data"
      ]
    },
    {
      "page": "icer",
      "title": "Incremental cost-effectiveness ratio",
      "topics": [
        "format.icer",
        "icer"
      ]
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